The End TB Strategy adopted by the World Health Assembly in 2014 aims to end the global tuberculosis (TB) epidemic by 2035 and to reduce TB deaths by 95%. The operationalisation of this strategy calls for innovative approaches and health technologies for TB prevention and care in the most vulnerable and most affected populations. Furthermore, bringing together researchers, end-users, decision-makers and program implementers is crucial to shorten time between the generation of scientific evidence and widespread adoption of policies and improved practices for childhood TB, that can contribute to reaching the Sustainable Development Goals (SDGs).